Stability-indicative deter
mination of ertapene
m (ERTM) in the presence of its β-lacta
m open-ring degradation product, which is also the
metabolite, is investigated. The degradation product has been isolated, via acid-degradation, characterized and elucidated. Selective quantification of ERTM, singly in bulk for
m, phar
maceutical for
mulations and/or in the presence of its
major degradant is de
monstrated.
The indication of stability has been undertaken under conditions likely to be expected at normal storage conditions. Among the spectrophotometric methods adopted for quantification are first derivative (1D), first derivative of ratio spectra (1DD) and bivariate analysis.