Differential diagnosis of neurodegenerative diseases using structural MRI data
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- 作者：Juha Koikkalainena ; i ; juha.koikkalainen@combinostics.com" class="auth_mail" title="E-mail the corresponding author ; Hanneke Rhodius-Meesterb ; Antti Tolonena ; Frederik Barkhofc ; Betty Tijmsb ; Afina W. Lemstrab ; Tong Tongd ; Ricardo Guerrerod ; Andreas Schuhd ; Christian Ledigd ; Daniel Rueckertd ; Hilkka Soininene ; Anne M. Remese ; Gunhild Waldemarg ; Steen Hasselbalchg ; Patrizia Mecoccih ; Wiesje van der Flierb ; f ; Jyrki Lö ; tjö ; nena ; i
- 关键词：MRI ; Neurodegenerative diseases ; Classification ; Volumetry ; TBM ; VBM ; Alzheimer's disease ; Frontotemporal lobar degeneration ; Vascular dementia ; Dementia with Lewy bodies
- 刊名：NeuroImage: Clinical
- 出版年：2016
- 出版时间：2016
- 年：2016
- 卷：11
- 期：Complete
- 页码：435-449
- 全文大小：1779 K
文摘
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Differential diagnostics of dementias was studied using structural MRI data.
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504 patients with both T1 and FLAIR MRIs from five patient classes were evaluated.
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Different fully automatic quantification methods were compared and combined.
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Classification accuracy of 70.6% was obtained for 5-class classification problem.
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Combination of several quantification methods was needed for optimal accuracy.