Exosomal MicroRNA Transport from Salivary Mesenchyme Regulates Epithelial Progenitor Expansion during Organogenesis

详细信息    查看全文

• 作者：Toru Hayashi¹ ; ² ; Isabelle M.A. Lombaert¹ ; ³ ; ⁴ ; Belinda R. Hauser¹ ; Vaishali N. Patel¹ ; Matthew P. Hoffman¹ ; ⁵ ; ^{mhoffman@mail.nih.gov}
• 关键词：microRNA ; exosomes ; miR-133b-3p ; DIP2B ; progenitor cells ; salivary gland ; epithelial-mesenchymal interaction ; KIT ; epigenetic repression ; 5-methylcytosine
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：40
• 期：1
• 页码：95-103
• 全文大小：3336 K
• 卷排序：40

文摘

Exosomal miRNAs are transported from mesenchyme to epithelium during organogenesis Exosomal mesenchymal miR-133b-3p is delivered to the epithelium but not transcribed miR-133b-3p targets DIP2B, which is involved in DNA methylation in KIT+ progenitors Exosomal miRNA epigenetically regulates genes controlling KIT+ progenitor expansion