The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR
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- 作者：Christopher J. Fiorese1 ; 2 ; 4 ; Anna M. Schulz1 ; 4 ; Yi-Fan Lin1 ; Nadine Rosin1 ; Mark W. Pellegrino1 ; Cole M. Haynes1 ; 2 ; 3 ; cole.haynes@umassmed.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Biology
- 出版年：2016
- 出版时间：8 August 2016
- 年：2016
- 卷：26
- 期：15
- 页码：2037-2043
- 全文大小：1619 K
文摘
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Mammalian ATF5 regulates the mitochondrial UPR in worms lacking ATFS-1
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ATF5 induces transcription of mammalian mitochondrial proteostasis genes
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ATF5 localizes to mitochondria and nuclei, suggesting regulation similar to ATFS-1
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ATF5 promotes mitochondrial function and recovery from mitochondrial stress