Parenchymal cystatin C focal deposits and glial scar formation around brain arteries in Hereditary Cystatin C Amyloid Angiopathy
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- 作者：Asbjorg Osk Snorradottira ; Helgi J. Isakssonb ; Stephan A. Kaeserc ; d ; Angelos A. Skodrasd ; c ; Elias Olafssone ; f ; Astridur Palsdottira ; g ; Birkir Thor Bragasona ; g ; birkirbr@hi.is" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hereditary Cystatin C Amyloid Angiopathy ; Cystatin C distribution ; Focal deposits ; Neuroinflammation ; Glial scar
- 刊名：Brain Research
- 出版年：2015
- 出版时间：5 October 2015
- 年：2015
- 卷：1622
- 期：Complete
- 页码：149-162
- 全文大小：6320 K
文摘
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This is a post-mortem study of brain pathology in HCCAA patients.
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The study addressed the topographical distribution and severity of brain cystatin C deposition.
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This study revealed focal parenchymal cystatin C deposits for the first time.
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The study addressed the neuroinflammatory response to cystatin C deposition.
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The neuroinflammatory response was limited to the vicinity of arteries and focal deposits.