Challenges in biomarker discovery with MALDI-TOF MS
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- 作者：Joanna Hajduk ; Jan Matysiak ; Zenon J. Kokot ; zkokot@ump.edu.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADHB ; o-alkylated dihydroxybenzoic acid ; ATHAP ; alkylated trihydroxyacetophenone ; CFU ; colony forming unit ; DHAP ; 2 ; 5-dihydroxyacetophenone ; DHB ; 2 ; 5-dihydroxybenzoic acid ; FDR ; false discovery rate ; HCCA ; alpha-cyano-4-hydroxycinnamic acid ; HILIC ; hydrophilic interaction chromatography ; HUPO ; human proteome organization ; ICAT ; isotope-coded affinity tag ; IMAC ; immobilized metal affinity chromatography ; ISD ; in-source decay ; iTRAQ ; isobaric tag for relative and absolute quantitation ; LC ; liquid
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：458
- 期：Complete
- 页码：84-98
- 全文大小：921 K
文摘
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MALDI-TOF MS technique is a popular tool in searching human diseases biomarkers.
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Sample preparation methods for capturing low molecular subproteomes
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MS data interpretation affected by preprocessing and statistical analysis step.
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High abundant proteins mostly pointed as potential biomarkers in profiling pattern.