Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes

详细信息    查看全文

• 作者：Christine M. Burrer^a ; ¹ ; Helen Auburn^a ; ¹ ; Xu Wang^b ; Juntao Luo^b ; Fardokht A. Abulwerdi^c ; Zaneta Nikolovska-Coleska^c ; Gary C. Chan^a ; ^{chang@upstate.edu}
• 关键词：Cytomegalovirus ; Monocytes ; Myeloid cell leukemia 1 ; Nanoparticles ; Small-molecule inhibitor
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：138
• 期：Complete
• 页码：40-46
• 全文大小：1804 K
• 卷排序：138

文摘

Mcl-1 inhibitors stimulate death of HCMV-infected monocytes. HCMV-infected monocytes exhibit enhanced uptake of nanoparticles. Encapsulated Mcl-1 inhibitors induce more potent killing of infected monocytes.