Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function
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- 作者：Guangsen Shi1 ; 6 ; Pancheng Xie1 ; 6 ; Zhipeng Qu1 ; Zhihui Zhang1 ; Zhen Dong1 ; Yang An1 ; Lijuan Xing2 ; Zhiwei Liu2 ; Yingying Dong2 ; Guoqiang Xu3 ; Ling Yang2 ; Yi Liu4 ; yi.liu@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Ying Xu1 ; 2 ; 5 ; yingxu@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：14
- 期：4
- 页码：823-834
- 全文大小：3091 K
文摘
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HDAC3 is a critical component of the core mammalian circadian negative feedback loop
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HDAC3 is required for efficient activation of E-box-driven gene expression
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HDAC3 blocks CRY1 degradation and promotes BMAL1 and CRY1 association
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Temporal separation of these opposing roles ensures robust circadian gene expression