Conserved aromatic residues as determinants in the folding and assembly of immunoglobulin variable domains
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- 作者：Stephen R. Campion ; stephen.campion@alvernia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amino-acid conservation ; Antibody structure-function ; Protein folding ; Immunoglobulin evolution ; Ig variable domains ; Conserved aromaticity
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：63-71
- 全文大小：6728 K
文摘
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Immunoglobulin VH and VL domains exhibit both shared and unique sites of conservation.
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Ig heavy- and light-chains share critical sites of conserved aromaticity.
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Conserved aromaticity is symmetrically concentrated in the VH–VL interface.
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A role for aromaticity in both the folding and assembly of antibody structure is postulated.