The repetitive portion of the Xenopus IgH Mu switch region mediates orientation-dependent class switch recombination
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- 作者：Zheng Z. Zhanga ; Nicholas R. Pannunzioa ; Zhengfei Lua ; Ellen Hsub ; Kefei Yuc ; Michael R. Liebera ;
- 关键词：IgH ; immunoglobulin heavy chain ; Ig CSR ; immunoglobulin class switch recombination ; XSm ; Xenopus IgH mu switch region ; CIT ; anti-CD40 ; iL4 ; TGF-β1
- 刊名：Molecular Immunology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：67
- 期：2
- 页码：524-531
- 全文大小：1523 K
文摘
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Xenopus Sμ (XSμ) has a highly repetitive 2 kb region rich in WGCW.
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The 2 kb XSμ forms R-loops when in the physiologic orientation in B cells.
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The 2 kb XSμ portion supports Ig CSR in B cells, but only in the forward orientation.
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The relation between R-loop formation and Ig CSR may be conserved in evolution.