Food diversity in infancy and the risk of childhood asthma and allergies

详细信息    查看全文

• 作者：Bright I. Nwaru ; MPhil ; PhD^a ; ^b ; ^{bright.nwaru@uta.fi" class="auth_mail} ; Hanna-Mari Takkinen ; MSc^a ; ^c ; Minna Kaila ; MD ; PhD^d ; ^e ; Maijaliisa Erkkola ; PhD^f ; Suvi Ahonen ; MSc^a ; ^g ; Juha Pekkanen ; MD ; PhD^h ; ⁱ ; Olli Simell ; MD ; PhD^j ; Riitta Veijola ; MD ; PhD^k ; Jorma Ilonen ; MD ; PhD^l ; ^m ; Heikki Hy&ouml ; ty ; MD ; PhDⁿ ; ^o ; Mikael Knip ; MD ; PhD^d ; ^p ; ^q ; ^r ; Suvi M. Virtanen ; MD ; PhD^a ; ^c ; ^d ; ^g
• 关键词：Asthma ; allergic rhinitis ; atopic eczema ; wheeze ; food diversity ; children
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：April, 2014
• 年：2014
• 卷：133
• 期：4
• 页码：1084-1091
• 全文大小：174 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Background

Recently, the bacterial diversity of the intestinal flora and the diversity of various environmental factors during infancy have been linked to the development of allergies in childhood. Food is an important environmental exposure, but the role of food diversity in the development of asthma and allergies in childhood is poorly defined.

Objective

We studied the associations between food diversity during the first year of life and the development of asthma and allergies by age 5 years.

Methods

In a Finnish birth cohort we analyzed data on 3142 consecutively born children. We studied food diversity at 3, 4, 6, and 12 months of age. Asthma, wheeze, atopic eczema, and allergic rhinitis were measured by using the International Study of Asthma and Allergies in Childhood questionnaire at age 5 years.

Results

By 3 and 4 months of age, food diversity was not associated with any of the allergic end points. By 6 months of age, less food diversity was associated with increased risk of allergic rhinitis but not with the other end points. By 12 months of age, less food diversity was associated with increased risk of any asthma, atopic asthma, wheeze, and allergic rhinitis.

Conclusion

Less food diversity during the first year of life might increase the risk of asthma and allergies in childhood. The mechanisms for this association are unclear, but increased聽dietary antigen exposure might contribute to this link.