Predicting Patient-Specific Expansion of Abdominal Aortic Aneurysms

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• 作者：F. Helderman ; I.J. Manoch ; M. Breeuwer ; U. Kose ; H. Boersma ; M.R.H.M. van Sambeek ; P.M.T. Pattynama ; O. Schouten ; D. Poldermans ; W. Wisselink ; A.F.W. van der Steen ; R. Krams
• 关键词：Abdominal aortic aneurysm ; Mechanical stress ; Risk factors
• 刊名：European Journal of Vascular and Endovascular Surgery
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：40
• 期：1
• 页码：47-53
• 全文大小：502 K

文摘

Objective

Local anatomy and the patient's risk profile independently affect the expansion rate of an abdominal aortic aneurysm. We describe a hybrid method that combines finite element modelling and statistical methods to predict patient-specific aneurysm expansion.

Methods

The 3-D geometry of the aneurysm was imaged with computed tomography. We used finite element methods to calculate wall stress and aneurysm expansion. Expansion rate was adjusted by risk factors obtained from a database of 80 patients. Aneurysm diameters predicted with and without the risk profiles were compared with diameters measured with ultrasound for 11 patients.

Results

For this specific group of patients, local anatomy contributed 62 % and the risk profile 38 % to the aneurysmal expansion rate. Predictions with risk profiles resulted in smaller root mean square errors than predictions without risk profiles (2.9 vs. 4.0 mm, p < 0.01).

Conclusions

This hybrid approach predicted aneurysmal expansion for a period of 30 months with high accuracy.