Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer: A DCOG late-effects study

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• 作者：Eva Clemens^a ; ^b ; ^{e.clemens@erasmusmc.nl} ; Andrica C. de Vries^a ; Saskia F. Pluijm^a ; ^b ; Antoinette am Zehnhoff-Dinnesen^c ; Wim J. Tissing^d ; Jacqueline J. Loonen^e ; Eline van Dulmen-den Broeder^f ; Dorine Bresters^g ; Birgitta Versluys^h ; Leontien C. Kremerⁱ ; Heleen J. van der Palⁱ ; Martine van Grotel^b ; Marry M. van den Heuvel-Eibrink^a ; ^b ; on behalf of DCOG-LATER ; The Netherlands
• 关键词：Cisplatin ; Carboplatin ; Ototoxicity ; Childhood cancer ; M&uuml ; nster classification ; Furosemide
• 刊名：European Journal of Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：69
• 期：Complete
• 页码：77-85
• 全文大小：406 K
• 卷排序：69

文摘

A higher total cumulative dose cisplatin is associated with a higher risk of ototoxicity. The risk of ototoxicity increased significantly up to a total cumulative dose cisplatin of 300 mg/m2. Children with younger age at diagnosis have an increased risk of ototoxicity after platinum treatment. Co-treatment with furosemide is independently associated with ototoxicity.