Alterations in the bone marrow microenvironment may elicit defective hematopoiesis: a comparison of aplastic anemia, chronic myeloid leukemia, and normal bone marrow

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• 作者：Meerim Park^a ; Chan-Jeoung Park^b ; ^{cjpark@amc.seoul.kr} ; Young Wook Cho^b ; Seongsoo Jang^b ; Jung-Hee Lee^c ; Je-Hwan Lee^c ; Kyoo-Hyung Lee^c ; Young Ho Lee^d ; ^{cord@hanyang.ac.kr}
• 刊名：Experimental Hematology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：45
• 期：Complete
• 页码：56-63
• 全文大小：628 K
• 卷排序：45

文摘

Decreased T and B lymphopoiesis was demonstrated in both aplastic anemia (AA) and chronic myeloid leukemia (CML). Natural killer cells were observed in AA, but were absent in CML and control. There were significant differences between of AA and CML stromal cell components. Alteration of the osteoblasts or sinusoidal endothelium could modify hematopoietic stem cell levels. Changes in the bone marrow microenvironment could lead to AA or CML.