Cytokines in nasal lavages and plasma and their correlation with clinical parameters in cystic fibrosis

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• 作者：Marthe S. Paats ; Ingrid M. Bergen ; Marleen Bakker ; Rogier A.S. Hoek ; Karin J. Nietzman-Lammering ; Henk C. Hoogsteden ; Rudi W. Hendriks ; Menno M. van der Eerden
• 关键词：Cystic fibrosis ; Cytokines ; Inflammation ; Nasal lavages ; Interleukin
• 刊名：Journal of Cystic Fibrosis
• 出版年：December, 2013
• 年：2013
• 卷：12
• 期：6
• 页码：623-629
• 全文大小：385 K

文摘

Background

Because persistent inflammation plays a dominant role in cystic fibrosis (CF), we assessed systemic and local upper airway responses during and after pulmonary exacerbation.

Methods

We followed a cohort of Pseudomonas aeruginosa-infected adult CF patients (n = 16) over time in pulmonary exacerbation and in stable disease. Interleukin (IL)-1尾, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-17A, IL-22, interferon-纬 and TNF伪 levels were measured in sputum, nasal lavages and plasma.

Results

In CF patients IL-6 and IL-10 levels in nasal lavages were significantly increased in exacerbation compared with stable disease. Systemic IL-6 significantly correlated with CRP levels and FEV1 (%predicted), independently of disease status. Systemic IL-10 also correlated significantly with CRP and FEV1 (%predicted), but only in exacerbation. Other cytokines tested did not discriminate between exacerbation and stable disease.

Conclusions

Determination of IL-6 and IL-10 in nasal lavages may provide a minimally invasive tool in the assessment of an exacerbation in CF.