The effects of age on health-related quality of life in cancer populations: A pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients
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- 作者：Chantal Quintena ; 1 ; chquinten@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Corneel Coensb ; 2 ; corneel.coens@eortc.be" class="auth_mail" title="E-mail the corresponding author ; Irina Ghislainb ; 3 ; irina.ghislain@eortc.be" class="auth_mail" title="E-mail the corresponding author ; Efstathios Zikosb ; 3 ; efstathios.zikos@eortc.be" class="auth_mail" title="E-mail the corresponding author ; Mirjam A.G. Sprangersc ; 4 ; m.a.sprangers@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author ; Jolie Ringashd ; 5 ; jolie.ringash@rmp.uhn.on.ca" class="auth_mail" title="E-mail the corresponding author ; Francesca Martinellib ; 6 ; francesca.martinelli@eortc.be" class="auth_mail" title="E-mail the corresponding author ; Divine E. Ediebahe ; 7 ; ediebahdivine@gmail.com" class="auth_mail" title="E-mail the corresponding author ; John Maringwaf ; 18 ; j.maringwa@wequantify.com" class="auth_mail" title="E-mail the corresponding author ; Bryce B. Reeveg ; 8 ; bbreeve@email.unc.edu" class="auth_mail" title="E-mail the corresponding author ; Eva Greimelh ; 9 ; elfriede.greimel@klinikum-graz.at" class="auth_mail" title="E-mail the corresponding author ; Madeleine T. Kingi ; 10 ; madeleine.king@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Kristin Bjordalj ; 11 ; kbj@ous-hf.no" class="auth_mail" title="E-mail the corresponding author ; Hans-Henning Flechtnerk ; 12 ; hans-henning.flechtner@med.ovgu.de" class="auth_mail" title="E-mail the corresponding author ; Joseph Schmucker-Von Kochl ; 13 ; joseph.schmucker-von-koch@psk.uni-regensburg.de" class="auth_mail" title="E-mail the corresponding author ; Martin J.B. Taphoornm ; n ; 14 ; m.taphoorn@mchaaglanden.nl" class="auth_mail" title="E-mail the corresponding author ; Joachim Weiso ; 15 ; weis@tumorbio.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Hans Wildiersp ; 16 ; hans.wildiers@uzleuven.be" class="auth_mail" title="E-mail the corresponding author ; Galina Velikovaq ; 17 ; G.Velikova@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Andrew Bottomleyb ; andrew.bottomley@eortc.be" class="auth_mail" title="E-mail the corresponding author ; on behalf of PROBE
- 关键词：Increasing age ; Cancer burden ; General population ; Normative data ; Health-related quality of life
- 刊名：European Journal of Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：51
- 期：18
- 页码：2808-2819
- 全文大小：960 K
文摘
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Data from 25 EORTC trials, including 6024 patients were pooled for this analysis
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Cancer patients have worse HRQOL compared to the general population, but the HRQOL domains that are impaired vary by age.
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Cancer patients report better HRQOL with increasing age for social and role functioning and financial problems.
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Cancer patients report worse HRQOL with increasing age for physical and cognitive functioning and constipation.
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HRQOL burden changed with age for each cancer site, but the magnitude and size differed between cancer sites.