Dynamics of in vivo hepatitis D virus infection
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- 作者：Ashish Goyal ; ashish.goyal@student.unsw.edu.au" class="auth_mail" title="E-mail the corresponding author ; John M. Murray
- 关键词：HDV ; Hepatitis D virus ; HBsAg ; hepatitis B Surface Antigen ; HBV ; Hepatitis B virus ; HCC ; hepatocellular carcinoma ; IFN ; pegylated interferon ; cccDNA ; covalently closed circular DNA ; pgRNA ; pregenomic RNA ; rcDNA ; double-stranded DNA-containing capsids ; AG-RNA ; anti-genomic RNA ; S-HDAg ; small delta antigen ; L-HDAg ; large delta antigen ; RNP ; ribonucleoprotein complex
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：7 June 2016
- 年：2016
- 卷：398
- 期：Complete
- 页码：9-19
- 全文大小：680 K
文摘
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HDV inhibits the feedback mechanism of HBV infection.
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Lower cccDNA accumulation is observed during HDV superinfection than coinfection.
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Prenylation can serve as an effective therapy for HDV infection.
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Long term high efficacy interferon therapy is essential to eradicate HBV and HDV.