Nucleic acid polymers: Broad spectrum antiviral activity, antiviral mechanisms and optimization for the treatment of hepatitis B and hepatitis D infection
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- 作者：Andrew Vaillant availlant@replicor.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatitis B virus ; Hepatitis delta virus ; HBsAg ; Nucleic acid polymer ; Antiviral therapy
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：133
- 期：Complete
- 页码：32-40
- 全文大小：1218 K
文摘
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NAPs block viral entry in many viruses including hepatitis B and hepatitis D.
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NAPs also have a post-entry activity against HBV consistent with HBsAg release inhibition.
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The post-entry activity of NAPs appears essential for antiviral activity in vivo.
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NAPs have therapeutic effect against chronic HBV and HDV infection in humans.
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Elimination of HBsAg by NAPs may improve the effect of immunotherapy.