Mixed-ligand copper(II) complexes activate aryl hydrocarbon receptor AhR and induce CYP1A genes expression in human hepatocytes and human cell lines
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- 作者：Kateřina Kube&scaron ; ová ; a ; Aneta Dořičá ; ková ; a ; Zdeněk Trá ; vní ; čekb ; Zdeněk Dvořá ; ka ; moulin@email.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：AhR ; aryl hydrocarbon receptor ; AR ; androgen receptor ; CYP ; cytochrome P450 ; DEX ; dexamethasone ; DHT ; dihydrotestosterone ; DMF ; N ; N dimethylformamide ; GR ; glucocorticoid receptor ; PXR ; pregnane X receptor ; RIF ; rifampicin ; RVT ; resveratrol ; T3 ; 3 ; 3&prime ; 5-triiodo-l-thyronine ; RXRs ; retinoid X receptors ; TAT ; tyrosine aminotransferase ; TCDD ; 2 ; 3 ; 7 ; 8-tetrachlorodibenzo-p-dioxin ; TR ; thyroid hormone receptor ; VD3 ; 25-hydroxyvitamin D3 ; VDR ; vitamin D receptor
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：25 July 2016
- 年：2016
- 卷：255
- 期：Complete
- 页码：24-35
- 全文大小：2630 K
文摘
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Mixed-ligand copper II complexes were studied.
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Transcriptional activity of TR, VDR, AR, GR, AhR and PXR receptors was measured.
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Target genes in primary human hepatocytes and cancer cell lines were determined.
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Two tested compounds activated AhR and induced CYP1A1 and CYP1A2.