Clinical and experimental research in antituberculosis drug-induced hepatotoxicity: a review
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- 作者：Udhaya Lavinya Baskaran ; Evan Prince Sabina ; eps674@gmail.com
- 关键词：antitubercular agents ; isoniazid ; rifampicin ; pyrazinamide ; oxidative stress ; complementary therapies
- 刊名：Journal of Integrative Medicine
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：15
- 期：1
- 页码：27-36
- 全文大小：256 K
- 卷排序：15
文摘
Drug-induced liver injury is the common adverse effect seen in patients receiving antituberculosis drugs (ATDs). There are several risk factors associated with the development of hepatotoxicity in such patients. Though there have been appreciable efforts taken by carrying out studies investigating the efficacy of several natural and synthetic compounds in minimising this effect, the only choice available for clinicians is withdrawal of drugs. This review would give a precise idea of ATD-induced hepatotoxicity, its underlying mechanisms and alternative therapies for the same.