Extra-gain of HER2-positive cases through HER2 reassessment in primary and metastatic sites in advanced gastric cancer with initially HER2-negative primary tumours: Results of GASTric cancer HER2 reassessment study 1 (GASTHER1)
详细信息 查看全文
- 作者：Sook Ryun Parka ; 1 ; Young Soo Parkb ; 1 ; Min-Hee Ryua ; 1 ; Baek-Yeol Ryooa ; Chang Gok Woob ; Hwoon-Yong Jungc ; Jeong Hoon Leec ; Gin Hyug Leec ; Yoon-Koo Kanga ; ykkang@amc.seoul.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：HER2 ; Gastric cancer ; Intratumoural heterogeneity ; Primary lesion ; Metastatic lesion ; Conversion ; Reassessment
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：42-50
- 全文大小：1100 K
文摘
- •
The intratumoural heterogeneity of human epidermal growth factor receptor 2 (HER2) status is a major challenge.
- •
We reassess HER2 in primary and metastatic sites in initially HER2(–) gastric cancer.
- •
Reassessment finds 8.7% (primary sites) and 5.7% (metastatic sites) HER2(+) disease.
- •
Patients with rescued HER2(+) have benefits from trastuzumab-containing therapy.
- •
We find significant clinical factors associated with rescued HER2 positivity.