- 作者：Jorge Garcí ; a Martí ; nez ; xurde_garcia@hotmail.com ; Jhudit Pé ; rez-Escuredo ; Dario Garcí ; a-Carracedo ; Marta Alonso-Guervó ; s ; Carlos Suá ; rez-Nieto ; José ; Luis Llorente-Pendá ; s ; Cé ; sar Á ; lvarez-Marcos ; Mario Hermsen
- 关键词：Carcinoma de cé ; lulas escamosas de laringe ; Inestabilidad de microsaté ; lites ; Quimioterapia
- 刊名：Acta Otorrinolaringol¨®gica Espa?ola
- 出版年：2012
- 出版时间：March-April, 2012
- 年：2012
- 卷：63
- 期：2
- 页码：79-84
- 全文大小：561 K
Introduction and objectives
The literature on the involvement of microsatellite instability in head and neck squamous cell carcinoma shows great variability, probably due to differences in the testing methods. Using a consensus detection system, we aimed to reach a reliable estimate of microsatellite instability prevalence in a subset of head and neck squamous cell carcinoma cases.
Methods
The microsatellite instabilityI status of 43 patients with previously untreated primary laryngeal squamous cell carcinomas was analyzed by a multiplex polymerase chain reaction assay including 5 mononucleotide repeat markers.
Results
Thirty-six cases showed a stable phenotype or a microsatellite stable phenotype (83.7 % ) and 7 cases (16.3 % ) showed an microsatellite instability-positive phenotype. One case showed instability in 3 of 5 markers, 1 case in 2 markers and 5 cases in 1 marker. The microsatellite instability-positive and stable cases did not differ with respect to age, tumour stage, lymph node or distant metastases.
Conclusions
Our data showed that a proportion of laryngeal squamous cell carcinomas are microsatellite instability positive. Knowledge of microsatellite instability patient status will allow adjusting anticancer therapy at an individual level.