Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways
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- 作者：Lena Seifert1 ; 4 ; Michael Deutsch1 ; 4 ; Sara Alothman1 ; Dalia Alqunaibit1 ; Gregor Werba1 ; Mridul Pansari1 ; Matthew Pergamo2 ; Atsuo Ochi1 ; Alejandro Torres-Hernandez1 ; Elliot Levie1 ; Daniel Tippens1 ; Stephanie H. Greco1 ; Shaun Tiwari1 ; Nancy Ngoc Giao Ly1 ; Andrew Eisenthal1 ; Eliza van Heerden1 ; Antonina Avanzi1 ; Rocky Barilla2 ; Constantinos P. Zambirinis1 ; Mauricio Rendon1 ; Donnele Daley1 ; H. Leon Pachter1 ; Cristina Hajdu2 ; George Miller1 ; 3 ; george.miller@nyumc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：liver fibrosis ; hepatocellular cancer ; C-type lectin receptors
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：13
- 期：9
- 页码：1909-1921
- 全文大小：7162 K
文摘
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Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer
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Deletion of Dectin-1 exacerbates liver fibrosis and accelerates hepatocarcinogenesis
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Dectin-1 protects against liver disease by suppressing TLR4 signaling
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Dectin-1 mitigates TLR4 and CD14 expression, which is regulated by M-CSF expression