Polymorphism in the CLOCK gene may influence the effect of fat intake reduction on weight loss
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We identified a genotype–diet interaction involving the m>CLOCKm> gene and fat intake.

Participants carrying m>rsm>3749474 (TT + CT) may benefit from dietary fat restriction.

The genetic variants had no significant influence on the change in obesity variables.

The present results may contribute to personalized dietary interventions.

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