Pulmonary artery vasoconstriction in rabbits is produced by 15(S)-HETE and by HETE analog 1.
Response to 15(S)-HETE is greater and sex-specific when compared to HETE analog 1.
15(S)-HETE produces more potent stimulation of vascular smooth muscle cell proliferation when compared to HETE analog 1.
In human hormone-independent prostate carcinoma PC-3 cells, HETE analog 1 inhibits proliferation and migration.
HETE analog 1 is a stable compound that will be a useful tool in future eicosanoid research.