(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid: A stable isomer of 15(S)-HETE that retains key vasoconstrictive and antiproliferative activity
详细信息 查看全文
- 作者：Sandra L. Pfistera ; spfister@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Peter G. Klimkob ; Raymond E. Conrowb
- 关键词：Arachidonic acid ; 15-Lipoxygenase ; 15-HETE ; Vasoconstriction ; Proliferation
- 刊名：Prostaglandins and Other Lipid Mediators
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：33-39
- 全文大小：827 K
文摘
- •
Pulmonary artery vasoconstriction in rabbits is produced by 15(S)-HETE and by HETE analog 1.
- •
Response to 15(S)-HETE is greater and sex-specific when compared to HETE analog 1.
- •
15(S)-HETE produces more potent stimulation of vascular smooth muscle cell proliferation when compared to HETE analog 1.
- •
In human hormone-independent prostate carcinoma PC-3 cells, HETE analog 1 inhibits proliferation and migration.
- •
HETE analog 1 is a stable compound that will be a useful tool in future eicosanoid research.