Association of GA/HbA1c ratio and cognitive impairment in subjects with type 2 diabetes mellitus

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• 作者：Tomoe Kinoshita ; Masashi Shimoda ; Junpei Sanada ; Yoshiro Fushimi ; Yurie Hirata ; Shintaro Irie ; Akihito Tanabe ; Atsushi Obata ; Tomohiko Kimura ; Hidenori Hirukawa ; Kenji Kohara ; Fuminori Tatsumi ; Shinji Kamei ; Shuhei Nakanishi ; Tomoatsu Mune ; Kohei Kaku ; Hideaki Kaneto ; ^{kaneto@med.kawasaki-m.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：GA/HbA1c ratio ; Cognitive impairment ; Type 2 diabetes mellitus ; Hypoglycemia ; Hasegawa dementia scale-revised
• 刊名：Journal of Diabetes and its Complications
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：30
• 期：8
• 页码：1452-1455
• 全文大小：190 K

文摘

The aim of this study was to search for factors influencing cognitive impairment and to clarify the association between the fluctuation of blood glucose levels and cognitive impairment in elderly Japanese subjects with type 2 diabetes.

Methods

We recruited 88 relatively elderly subjects (≥ 65 years old) with type 2 diabetes who were hospitalized in Kawasaki Medical School from January 2014 to December 2015. We evaluated the fluctuation of blood glucose levels with glycoalbumin (GA)/hemoglobin A1c (HbA1c) ratio, and estimated cognitive impairment with Hasegawa dementia scale-revised (HDS-R) score and mini mental state examination (MMSE) score.

Results

Multivariate analyses showed that GA/HbA1c ratio and urinary albumin excretion, but not hypoglycemia, were independent determinant factors for cognitive impairment in elderly Japanese subjects with type 2 diabetes.

Conclusions

The fluctuation of blood glucose levels per se is closely associated with cognitive impairment in elderly subjects with type 2 diabetes even when hypoglycemia is not accompanied. Since it is very easy to calculate GA/HbA1c ratio, we should check this ratio so that we can reduce the fluctuation of blood glucose levels especially in elderly subjects with type 2 diabetes.