Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis

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• 作者：Yayoi Kamata ; PhD^a ; Utako Kimura ; MD ; PhD^b ; Hironori Matsuda^a ; Suhandy Tengara ; MD ; PhD^a ; Atsuko Kamo ; PhD^a ; Yoshie Umehara ; PhD^a ; Kyoichi Iizumi ; PhD^a ; Hiroaki Kawasaki ; PhD^a ; Yasushi Suga ; MD ; PhD^b ; Hideoki Ogawa ; MD ; PhD^a ; Mitsutoshi Tominaga ; PhD^a ; ^{tominaga@juntendo.ac.jp} ; Kenji Takamori ; MD ; PhD^a ; ^b ; ^{ktakamor@juntendo.ac.jp}
• 关键词：AD ; atopic dermatitis ; CTLs ; cytotoxic T lymphocytes ; EDTA ; ethylenediaminetetraacetic acid ; ELISA ; enzyme-linked immunosorbent assay ; GRP ; gastrin releasing peptide ; Gzm ; granzyme ; PASI ; psoriasis area and severity index ; SCORAD ; scoring atopic dermatitis ; VAS ; visual analogue scale
• 刊名：Journal of Dermatological Science
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：84
• 期：3
• 页码：266-271
• 全文大小：1279 K
• 卷排序：84

文摘

Plasma granzyme (Gzm) B level increased in atopic dermatitis (AD) patients. Plasma GzmB level correlated with severity of dermatitis including pruritus in AD. Plasma GzmB level uncorrelated with severity of itch and dermatitis in psoriasis.