Roles of OCT4 in tumorigenesis, cancer therapy resistance and prognosis
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- 作者：Emilly Schlee Villodrea ; emillyvillodre@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Franciele Cristina Kippera ; franciele.kipper@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Mariana Brutschin Pereiraa ; mbrutschin@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Guido Lenza ; b ; lenz@ufrgs.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：CSCs ; cancer stem cells ; DNA ; deoxyribonucleic acid ; ECCs ; embryonal carcinoma cells ; ESCs ; embryonic stem cells ; ESCC ; esophageal squamous cell carcinoma ; GC ; gastric cancer ; HCC ; hepatocellular carcinoma ; HIFs ; hypoxia-inducible factors ; HSCC ; hypopharyngeal squamous cell carcinoma ; hMSCs ; human mesenchymal stem cells ; iPS ; induced pluripotent cells ; lncRNA ; long non-coding RNA ; miRNA ; microRNA ; OCT4 ; octamer 4 or POU5F1 ; OCT4-pg ; OCT4 pseudogene ; OSCC ; oral squamous cell carcinoma ; pMEFs ; pri
- 刊名：Cancer Treatment Reviews
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：51
- 期：Complete
- 页码：1-9
- 全文大小：682 K
文摘
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OCT4 is one of the most important regulator in pluripotency.
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OCT4 isoforms/pseudogenes may add uncertainty in the analysis of OCT4 in cancer.
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OCT4 enhances tumorigenesis and progression of different types of cancer.
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Therapy-resistant cells present higher levels of OCT4 than sensitive ones.
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OCT4 correlates with worse cancer outcome in most tumors.