Outcomes of various transplant procedures (single, sparing, inverted) in living-donor lobar lung transplantation

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• 作者：Hiroshi Date ; MD^a ; ^{hdate@kuhp.kyoto-u.ac.jp} ; Akihiro Aoyama ; MD^a ; Kyoko Hijiya ; MD^a ; Hideki Motoyama ; MD^a ; Tomohiro Handa ; MD^b ; Hideyuki Kinoshita ; MD^c ; Shiro Baba ; MD^d ; Toshiyuki Mizota ; MD^e ; Kenji Minakata ; MD^f ; Toyofumi F. Chen-Yoshikawa ; MD^a
• 关键词：living-donor lobar lung transplantation ; single lobe transplant ; native upper lobe&ndash ; sparing transplant ; right-left inverted transplant ; oversized graft ; undersized graft ; size matching
• 刊名：The Journal of Thoracic and Cardiovascular Surgery
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：153
• 期：2
• 页码：479-486
• 全文大小：811 K
• 卷排序：153

文摘

In standard living-donor lobar lung transplantation (LDLLT), the right and left lower lobes from 2 healthy donors are implanted. Because of the difficulty encountered in finding 2 donors with ideal size matching, various transplant procedures have been developed in our institution. The purpose of this retrospective study was to compare outcomes of nonstandard LDLLT with standard LDLLT.MethodsBetween June 2008 and January 2016, we performed 65 LDLLTs for critically ill patients. Functional size matching was performed by estimating graft forced vital capacity based on the donor's measured forced vital capacity and the number of pulmonary segments implanted. For anatomical size matching, 3-dimensional computed tomography volumetry was performed. In cases of oversize mismatch, single-lobe transplant or downsizing transplant was performed. In cases of undersize mismatch, native upper lobe sparing transplant or right-left inverted transplant was performed. In right-left inverted transplants, the donor's right lower lobe was inverted and implanted into the recipient's left chest cavity.ResultsTwenty-nine patients (44.6%) received nonstandard LDLLT, including 12 single-lobe transplants, 7 native upper lobe sparing transplants, 6 right-left inverted transplants, 2 sparing + inverted transplants, and 2 others. Thirty-six patients (57.4%) received standard LDLLT. Three- and five-year survival rates were similar between the 2 groups (89.1% and 76.6% after nonstandard LDLLT vs 78.0% and 71.1% after standard LDLLT, P = .712).ConclusionsVarious transplant procedures such as single, sparing and inverted transplants are valuable options when 2 donors with ideal size matching are not available for LDLLT.