- 作者：Mai S. Sater ; Ramzi R. Finan ; Farah M. Abu-Hijleh ; Tala M. Abu-Hijleh ; Wassim Y. Almawi
- 关键词：Autoantibodies ; Cardiolipin ; Phosphatidylserine ; Recurrent miscarriage
- 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
- 出版年：2012
- 出版时间：August, 2012
- 年：2012
- 卷：163
- 期：2
- 页码：170-174
- 全文大小：196 K
Objective
To investigate the association of antibodies to ¦Â2-glycoprotein I (anti-¦Â2GPI), cardiolipin (ACA), phosphatidylserine (anti-PS) and prothrombin (anti-PT) with recurrent spontaneous miscarriage (RSM).Study design
Case-control study involving 277 RSM cases and 288 controls: autoantibody levels were measured by ELISA. Differences between cases and controls were analyzed by nonparametric Mann-Whitney test, and logistic regression was used in analyzing the association of autoantibodies with RSM.
Results
Anti-PS IgG, ACA IgM and IgG, and anti-PT IgM were significantly associated with RSM risk, and differential antibody association was noted according to BMI and primary and secondary RSM. Higher prevalence of elevated anti-PS IgG was seen in cases, with the strongest risk above the 99th percentile. For ACA IgM, 28 cases (10.1 % ) and 5 controls (1.7 % ) were positive, with increasing OR for increasing cut-off points, which was significant at antibody titers >99th percentile. For ACA IgG, 101 cases (36.5 % ) and 13 controls (4.5 % ) were positive, with graded increase in OR for increasing cut-off points, which was significant at titers >90th percentile (maximal at titers >99th percentile). For anti-PT, 23 cases (12.0 % ) and 9 controls (6.1 % ) were positive, with increased OR at titers >90th percentile. Regression analyses confirmed the independent association of anti-PS IgG, ACA IgM and IgG with RSM, and significant RSM risk was associated with high anti-PS IgG (
Conclusion
Elevated ACA IgM and IgG, and anti-PS IgG antibodies are positively associated with RSM.