• 作者：Gabriel Sampol^a ; ^b ; ^{gsampol@vhebron.net} ; Gloria Rodé ; s^a ; José ; Rí ; os^c ; Odile Romero^b ; ^d ; Patrí ; cia Lloberes^a ; ^b ; Ferran Morell^a ; ^b
• 关键词：Apneas del sueñ ; o ; Insuficiencia respiratoria ; Hipercapnia ; Sueñ ; o ; Enfermedad pulmonar obstructiva cró ; nica
• 刊名：Archivos de Bronconeumolog¨ªa
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：46
• 期：9
• 页码：466-472
• 全文大小：266 K

Introduction

Acute hypercapnic respiratory failure (AHRF) is a serious condition observed in some patients with sleep apnea-hypopnea syndrome (SAHS). The objective of the present study was to study the clinical characteristics of SAHS patients who develop AHRF and their prognosis.

Patients and method

A total of 70 consecutive SAHS patients who survived an AHRF episode and 70 SAHS patients paired by age with no previous history of AHRF were prospectively studied and followed up for 3 years.

Results

The deterioration of lung function due to obesity or concomitant chronic obstructive pulmonary diseases (COPD) was common in SAHS patients with AHRF. In the multivariate analysis, the risk factors associated with AHRF were baseline PaO_2, the theoretical percentage value of the forced vital capacity, alcohol consumption, and benzodiazepines. The mortality during follow up was higher among patients who had AHRF than in the control group. The main cause of death was respiratory, and the coexistence of COPD was identified as a mortality risk factor.

Conclusions

The development of AHRF in SAHS patients is associated with a deterioration in lung function and with alcohol and benzodiazepine consumption. The patients had a higher mortality after the AHRF episode, mainly a respiratory cause. New studies are required that evaluate the different available therapeutic options in these patients.