Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass
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- 作者：Daisuke Sakano1 ; Sungik Choi2 ; Masateru Kataoka2 ; Nobuaki Shiraki1 ; Motonari Uesugi3 ; Kazuhiko Kume4 ; Shoen Kume1 ; skume@bio.titech.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：pancreas ; insulin ; proliferation ; apoptosis ; dedifferentiation ; diabetes
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：12 July 2016
- 年：2016
- 卷：7
- 期：1
- 页码：95-109
- 全文大小：3173 K
文摘
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Dopamine inhibits dedifferentiation and proliferation, and promotes apoptosis of β cells
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Dopamine confers its action through binding to DRD2 and decreasing cAMP
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Dopamine-DRD2 signal also functions through interaction with adenosine-ADORA2A signal
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Dopamine-DRD2-cAMP signal is a potential target for β cell regeneration