Role of OATP2A1 in PGE2 secretion from human colorectal cancer cells via exocytosis in response to oxidative stress
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- 作者：Taku Kasai1 ; Takeo Nakanishi1 ; Yasuhiro Ohno ; Hiroaki Shimada ; Yoshinobu Nakamura ; Hiroshi Arakawa ; Ikumi Tamai ; tamai@p.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：BCG ; bromocresol green ; BIM ; bisindolylmaleimide ; BSP ; bromosulfophthalein ; COX ; cyclooxygenase ; CRC ; colorectal cancer ; EGTA ; ethylene glycol tetraacetic acid ; EP ; prostaglandin E receptor ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; 15-PGDH ; 15-hydroxyprostaglandin dehydrogenase ; HPRT1 ; hypoxanthine guaninephosphoribosyl transferase ; MAPK ; mitogen-activated protein kinase ; NAC ; N-acetyl-L-cysteine ; NS ; non-specific ; OATP ; organic anion transporting polypeptide ; PGE2 ; prostaglandin E2 ; ROS
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：341
- 期：2
- 页码：123-131
- 全文大小：3879 K
文摘
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OATP2A1 is expressed in cytoplasmic domains of colorectal cancer LoVo cells.
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Oxidative stress shifted OATP2A1 toward plasma membranes in LoVo cells.
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Exocytosis inhibitors decreased PGE2 release from LoVo cells treated with H2O2.
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OATP2A1 is involved in PGE2 exocytosis from LoVo cells due to oxidative stress.