ZHD of Bcd1p contributes to the steady-state level of the box C/D snoRNAs and is essential for cellular viability.
The 3D solution structure of ZHDs of Bcd1p and Hit1p was determined by NMR.
Bcd1p ZDH is functionally interchangeable with Hit1p ZDH, another box C/D snoRNP assembly factor.
Mutation of the ZnF2 motif in the ZHD of Bcd1p induces a heat-sensitive phenotype in yeast.
The Bcd1p ZHD is a functional fold stabilizer.