Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition
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- 作者：Benjamin Albright ; M.D. ; M.S.<sup>asup> ; Roni Dhaher ; Ph.D.<sup>asup> ; Helen Wang ; B.S.<sup>asup> ; Roa Harb ; M.D.<sup>asup> ; Tih-Shih W. Lee ; M.D. ; Ph.D.<sup>bsup> ; Hitten Zaveri ; Ph.D.<sup>csup> ; Tore Eid ; M.D. ; Ph.D<sup>asup><sup> ; sup><sup>tore.eid@yale.edusup>
- 关键词：c-Fos ; Entorhinal cortex ; Epileptogenesis ; Hippocampus ; Limbic structures
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：288
- 期：Complete
- 页码：122-133
- 全文大小：2188 K
- 卷排序：288
文摘
Inhibition of glutamine synthetase in the hippocampal formation leads to epilepsy. The epileptic seizures involve a small number of brain areas initially. The seizures are mostly low grade (not severe) during the early phase. The seizures progressively worsen over the next several weeks. The worsening is accompanied by seizure involvement of multiple brain areas.