PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats
详细信息 查看全文
- 作者：Jerry J. Floresa ; Damon Klebea ; William B. Rollanda ; Tim Lekica ; Paul R. Kraffta ; John H. Zhanga ; b ; johnzhang3910@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PPARγ ; CD36 ; Germinal matrix hemorrhage ; Post-hemorrhagic ventricular dilation ; Hematoma resolution
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：87
- 期：Complete
- 页码：124-133
- 全文大小：1423 K
文摘
- •
Treatment with 15d-PGJ2 after germinal matrix hemorrhage in neonatal rats
- •
PPARγ stimulation, CD36 scavenger receptor, and microglia/macrophage activation
- •
Enhanced hematoma resolution and improved long-term brain morphological outcomes
- •
Attenuated long-term neurofunctional deficits