Sestrin2 expression levels are dependent on the severity of neonatal brain injury.
Moderate and severe neonatal brain injuries induce sestrin2 expression differently.
Sestrin2 is induced by HIF1α upon severe but not moderate neonatal brain injury.
Sestrin2 has a protective effect on BBB after neonatal brain injury.
HIF1α exerts biphasic effects in moderate and severe neonatal brain models.