Nanosized magnetofluorescent Fe₃O₄–curcumin conjugate for multimodal monitoring and drug targeting

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• 作者：Lam Dai Tran ; Nhung My T. Hoang ; Trang Thu Mai ; Hoang Vinh Tran ; Ngoan Thi Nguyen ; Thanh Dang Tran ; Manh Hung Do ; Qui Thi Nguyen ; Dien Gia Pham ; Thu Phuong Ha ; Hong Van Le ; Phuc Xuan Nguyen
• 关键词：Magnetofluorescent Fe₃O₄ ; Curcumin (Cur) ; Macrophages ; Chitosan (CS) ; Oleic acid (OL) ; Laser scanning confocal microscope (LSCM) ; Physical properties measurement systems (PPMS)
• 刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
• 出版年：2010
• 出版时间：20 November 2010
• 年：2010
• 卷：371
• 期：1-3
• 页码：104-112
• 全文大小：2695 K

文摘

Magnetic drug targeting, the targeting of a drug conjugated with a magnetic material under the action of external magnetic field constitutes an important drug delivery system. This paper describes the strategy to design a multifunctional, nanosized magnetofluorescent water-dispersible Fe₃O₄–curcumin conjugate and its multiple ability to label, target and treat the tumor cells. The conjugate possesses magnetic nano Fe₃O₄ core, chitosan (CS) or oleic acid (OL) as outer shell and entrapped curcumin (Cur), serving dual function of naturally autofluorescent dye as well as anti-tumor model drug, delivered to the cells with the help of macrophage (Cur possesses anti-oxidant, anti-inflammatory and anti-tumor ability). Fe₃O₄–Cur conjugate exhibited a high loading cellular uptake which was clearly visualized dually by Fluorescence Microscope, Laser scanning confocal microscope (LSCM) as well as magnetization measurement (Physical properties measurement systems, PPMS). Preliminary magnetic resonance imaging (MRI) study also showed a clear contrast enhancement by using Fe₃O₄–Cur conjugate.