Synthesis and cytotoxic evaluation of novel dihydrobenzo[h]cinnoline-5,6-diones

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• 作者：Tuyet Anh Dang Thi^a ; Lena Decuyper^b ; Hoang Thi Phuong^a ; Doan Vu Ngoc^a ; Ha Thanh Nguyen^a ; Tra Thanh Nguyen^a ; Thanh Do Huy^a ; Hung Huy Nguyen^c ; Matthias D&rsquo ; hooghe^b ; Tuyen Van Nguyen^a ; ^{ngvtuyen@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dihydrobenzo[h]cinnoline-5 ; 6-diones ; Domino reactions ; Naphthoquinones ; Cytotoxicity
• 刊名：Tetrahedron Letters
• 出版年：2015
• 出版时间：21 October 2015
• 年：2015
• 卷：56
• 期：43
• 页码：5855-5858
• 全文大小：486 K

文摘

A convenient one-pot multicomponent synthetic approach was developed en route to novel functionalized dihydrobenzo[h]cinnoline-5,6-diones using 2-hydroxy-1,4-naphthoquinone, methylhydrazine, and a variety of aromatic aldehydes. Fifteen new derivatives were thus prepared and subsequently evaluated in terms of their cytotoxicity profile, revealing a promising anticancer activity of nine of the compounds against KB and Hep-G2 human tumor cell lines.