Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma

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• 作者：Martin Grimm ; MD ; DDS ; PhD^a ; ^{dr.dr.martingrimm@googlemail.com" class="auth_mail" title="E-mail the corresponding author} ; Oliver Feyen ; PhD^b ; Johannes F. Coy ; PhD^b ; Heiko Hofmann ; PhD^c ; Peter Teriete ; PhD^d ; Siegmar Reinert ; MD ; DDS ; PhD^a
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：121
• 期：3
• 页码：301-306
• 全文大小：802 K

文摘

Monocytes/macrophages are regarded as the first line of defense in tumors. Therefore, analyzing monocyte subtypes in oral squamous cell carcinoma (OSCC) may be of value in disease monitoring and to explore immunotherapeutic strategies for cancer patients.

Study Design

Circulating peripheral blood CD14+/CD16+ monocyte-derived macrophages (MDMs) were evaluated in OSCC patients with oral squamous cell carcinoma (n = 44) compared with controls (n = 85). Moreover, epitope detection in monocytes (EDIM) technology was used to detect biomarkers Apo10 and transketolase-like-1 in CD14+/CD16+ MDMs.

Results

Compared with controls, no significant (P = .3646) difference (control group 9.8%, OSCC group 8.8%) in CD14+/CD16+ MDM were noted in OSCC. However, EDIM-Apo10 and EDIM-TKTL1 scores detected in the CD14+/CD16+ MDMs were increased in OSCC compared with controls (P < .0001).

Conclusions

Analyzing CD14+/CD16+ MDMs represents a stable cell population for detecting biomarkers in cancer disease monitoring.