All New Zealand and non-New Zealand honeys are capable of inducing TNF-α release from blood monocytes, except for amber honey. The different honeys differed greatly in their immunostimulatory activity. Arabinogalactan proteins (AGPs) and apisimin are commonly present in both New Zealand and non-New Zealand honeys at different concentrations. The levels of apisimin and AGPs levels did not correlate exactly with the immunostimulatory activity of a particular honey type.