Measuring Health-Related Quality of Life in Leukemia: The Functional Assessment of Cancer Therapy - Leukemia (FACT-Leu) Questionnaire

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• 作者：David Cella ; PhD¹ ; ² ; ^{d-cella@northwestern.edu} ; Sally E. Jensen ; PhD¹ ; ⁴ ; Kimberly Webster ; MA¹ ; Du Hongyan ; MS³ ; Jin-Shei Lai ; PhD¹ ; ² ; Steven Rosen ; MD² ; Martin S. Tallman ; MD⁵ ; Susan Yount ; PhD¹ ; ²
• 关键词：acute leukemia ; chronic leukemia ; health-related quality of life ; patient-reported outcomes
• 刊名：Value in Health
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：15
• 期：8
• 页码：1051-1058
• 全文大小：286 K

文摘

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ABSTRACT

Objective

Develop and validate a health-related quality-of-life (measure for patients with acute and chronic leukemia.

Methods

The study consisted of two phases: scale construction and scale validation. For the item-generation phase, a summary of the literature combined with qualitative results from item-generation interviews with 29 acute or chronic leukemia patients and 16 health care providers yielded an initial item pool reflecting leukemia-specific concerns and symptoms. Items underwent iterations of review and reduction according to defined retention criteria to support content validity, as defined by priority concerns of patients. Seventeen final leukemia-specific items were combined with the Functional Assessment of Cancer Therapy-General to create the FACT-Leukemia (FACT-Leu) scale. For the validation phase, 79 individuals with acute or chronic leukemia completed questionnaires at three time points.

Results

All FACT-Leu subscale and aggregated scores showed high internal consistency (¦Ás ranging from 0.75 to 0.96). Test-retest reliability was adequate for all subscales (intraclass correlation range 0.765-0.890). The FACT-Leu scale demonstrated good convergent validity, with significant correlations with quality-of-life criteria and performance status, in the expected direction. FACT-Leu subscale scores were significantly different among the three performance status change groups, suggesting good responsiveness to change.

Conclusions

The FACT-Leu scale is a valid, reliable, and efficient measure of leukemia-specific health-related quality of life for acute and chronic disease.