L-DOPA modulates cell viability through the ERK-c-Jun system in PC12 and dopaminergic neuronal cells
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- 作者：Keun Hong Park ; Keon Sung Shin ; Ting Ting Zhao ; Hyun Jin Park ; Kyung Eun Lee ; Myung Koo Lee ; myklee@chungbuk.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：L-DOPA ; Epac ; ERK1/2 ; c-Jun ; PC12 cells ; Rat model of Parkinson's disease
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：87-97
- 全文大小：2362 K
文摘
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In PC12 cells, non-toxic L-DOPA induced cell survival by c-Jun activation (Ser73).
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Toxic L-DOPA treatment induced c-Jun phosphorylation (Ser63) and c-Jun expression.
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Multiple treatments with L-DOPA (20 μM) also induces c-Jun phosphorylation (Ser63).
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These conditions subsequently led to cell death by Epac-sustained ERK-c-Jun system.
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These results were validated by long-term L-DOPA administration in a rat model of PD.