Systematic review and meta-analysis of phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction

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• 作者：Liang Gao^a ; ^b ; ¹ ; Lu Yang^a ; ¹ ; Shengqiang Qian^a ; ^b ; Tao Li^a ; Ping Han^a ; Jiuhong Yuan^a ; ^b ; ^{jiuhongyuan2107@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Female sexual dysfunction ; Meta-analysis ; Phosphodiesterase type 5 inhibitor (PDE5i) ; Sildenafil
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：133
• 期：2
• 页码：139-145
• 全文大小：1074 K

文摘

Clinical studies evaluating the effectiveness and safety of phosphodiesterase type 5 inhibitors (PDE5is) for female sexual dysfunction have reported conflicting results.

Objectives

To systematically review evidence from studies comparing PDE5is with placebo in the treatment of female sexual dysfunction.

Search strategy

Searches of PubMed, the Cochrane Library, and Embase databases were performed using the MeSH terms “females/female/women”, “sexual”, and “sildenafil/tadalafil/vardenafil/PDE5/PDE5i”.

Selection criteria

All randomized controlled trials, available in English, published no later than January 28, 2015 comparing the effectiveness of PDE5is, or PDE5is in combination with other agents, with placebo in improving female sexual function were included.

Data collection and analysis

The inclusion criteria were met by 14 studies, which were analyzed by two reviewers.

Main results

The randomized controlled trials included in the present study adopted different questionnaires for measuring sexual function; consequently, most of the data had to be considered separately rather than pooled. Generally, the use of PDE5is resulted in significant improvements in sexual function compared with placebo, with some studies demonstrating negative results. Pooled data regarding adverse events demonstrated significantly higher rates of headache, flushing, and changes in vision in PDE5i-treated patients.

Conclusions

PDE5is could be an effective treatment modality for female sexual dysfunction. Although there were significant increases in adverse events in comparison with placebo, PDE5is were still relatively safe.