Facile one-pot tandem synthesis of perfluoroalkylated indolizines under metal-free mild conditions

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• 作者：Dong He^a ; ¹ ; Yuhong Xu^a ; ¹ ; Jing Han^a ; Hongmei Deng^b ; Min Shao^b ; Jie Chen^a ; Hui Zhang^a ; ^b ; ^{yehao7171@shu.edu.cn} ; Weiguo Cao^a ; ^c ; ^d ; ^e ; ^{wgcao@staff.shu.edu.cn}
• 关键词：Indolizine ; Perfluoroalkylated ; One-pot reaction ; Metal-free ; Tandem synthesis
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：16 February 2017
• 年：2017
• 卷：73
• 期：7
• 页码：938-944
• 全文大小：526 K
• 卷排序：73

文摘

A direct metal-free method for the synthesis of perfluoroalkylated indolizines by means of DIPEA-promoted tandem CN/CC bond formation was developed. Various substituted pyridines and bromoacetyl derivatives with methyl perfluoroalk-2-ynoates proceeded smoothly in this mild transformation, and the desired products were obtained in good to excellent yields under air.