Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy

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• 作者：Zhiguo Zhou^a ; Yanan Sun^a ; Jinchao Shen^a ; Jie Wei^a ; Chao Yu^a ; Bin Kong^a ; Wei Liu^a ; Hong Yang^a ; Shiping Yang^a ; ^b ; ^{shipingy@shnu.edu.cn" class="auth_mail} ; Wei Wang^c ; ^{wwang@unm.edu" class="auth_mail}
• 关键词：Iron/iron oxide nanoparticles ; Magnetic targeting ; Theranostics ; Photothermal therapy ; In vivo
• 刊名：Biomaterials
• 出版年：August 2014
• 年：2014
• 卷：35
• 期：26
• 页码：7470-7478
• 全文大小：3422 K

文摘

The development of photothermal agents (PTAs) with good stability, low toxicity, highly targeting ability and photothermal conversion efficiency is an essential pre-requisite to near-infrared photothermal therapy (PTT) in vivo. Herein, we report the readily available PEGylated Fe@Fe₃O₄ NPs, which possess triple functional properties in one entity – targeting, PTT, and imaging. Compared to Au nanorods, they exhibit comparable photothermal conversion efficiency (∼20%), and much higher photothermal stability. They also show a high magnetization value and transverse relaxivity (∼156 mm⁻¹ s⁻¹), which should be applied for magnetic targeting MRI. With the Nd-Fe-B magnet (0.5 T) beside the tumour for 12 h on the xenograft HeLa tumour model, PEGylated Fe@Fe₃O₄ NPs exhibit an obvious accumulation. In tumour, the intensity of MRI signal is ∼ three folds and the increased temperature is ∼ two times than those without magnetic targeting, indicating the good magnetic targeting ability. Notably, the intrinsic high photothermal conversion efficiency and selective magnetic targeting effect of the NPs in tumour play synergistically in highly efficient ablation of cancer cells in vitro and in vivo.