Infection by Cx43 adenovirus increased chemotherapy sensitivity in human gastric cancer BGC-823 cells: not involving in induction of cell apoptosis
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- 作者：Dan Liua ; 1 ; Hongfeng Zhoua ; 1 ; Jin Wua ; wujintree@163.com" class="auth_mail" title="E-mail the corresponding author ; Wentao Liua ; Yongqing Lib ; Guangyue Shia ; Xiaolong Yuea ; Xiwen Sunc ; Yanbin Zhaoa ; Xiaowei Hua ; Tianjiao Wanga ; Xufeng Zhanga
- 关键词：Connexon43 ; (CX43) ; Doxorubicin ; (Dox) ; Fluorouracil ; (5-Fu) ; Oxaliplatin ; (OXA)
- 刊名：Gene
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：574
- 期：2
- 页码：217-224
- 全文大小：1469 K
文摘
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Infection with Cx43 adenovirus, cell proliferation ability decreased and the sensitivity to chemotherapy drugs increased.
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The increasing Cx43 expression was accompanied by decreasing Pgp expression and MDR1 m RNA levels.
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Cx43 overexpression dose not affect apoptosis-related proteins and cell apoptosis rate increased insignificantly.