Leukotriene B4 induces EMT and vimentin expression in PANC-1 pancreatic cancer cells: Involvement of BLT2 via ERK2 activation

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• 作者：You Ri Kim¹ ; Mi Kyung Park¹ ; Gyeong Jin Kang ; Hyun Ji Kim ; Eun Ji Kim ; Hyun Jung Byun ; Moo-Yeol Lee ; Chang Hoon Lee ; ^{uatheone@dongguk.edu}
• 关键词：LTB4 ; BLT2 ; Vimentin ; EMT ; Comp A ; ERK2
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：115
• 期：Complete
• 页码：67-76
• 全文大小：1598 K
• 卷排序：115

文摘

LTB4 induces EMT in PANC-1 pancreatic cancer cells. LTB4 induces vimentin expression in several cancer cells including PANC-1 cells. BLT2 is involved in LTB4-induced vimentin expression in PANC-1 cells. ERK is involved in LTB4/BLT2-induced vimentin expression in PANC-1 cells. Cigarette extracts induces BLT2 expression in PANC-1 cells.