Prostate-derived ets factor represses tumorigenesis and modulates epithelial-to-mesenchymal transition in bladder carcinoma cells

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• 作者：Ke-Hung Tsui^a ; ^b ; ¹ ; Yu-Hsiang Lin^a ; ^c ; ¹ ; Li-Chuan Chung^d ; Sung-Ting Chuang^d ; Tsui-Hsia Feng^e ; Kun-Chun Chiang^f ; Phei-Lang Chang^a ; ^b ; Chi-Ju Yeh^g ; Horng-Heng Juang^a ; ^d ; ^{hhj143@mail.cgu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Bladder ; PDEF ; MASPIN ; NDRG family genes ; Invasion ; Tumorigenesis
• 刊名：Cancer Letters
• 出版年：2016
• 出版时间：28 May 2016
• 年：2016
• 卷：375
• 期：1
• 页码：142-151
• 全文大小：2689 K

文摘

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d="p0010">The role and function of PDEF in bladder carcinoma is still unknown.

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d="p0015">Our results showed that PDEF attenuated bladder carcinoma cell growth in vitro and in vivo.

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d="p0020">PDEF modulates gene expressions of BTG2, NDRG1, MASPIN, and KAI1.

dd><dt class="label">•dt><dd>

d="p0025">PDEF blocks EMT and F-actin polymerization in bladder carcinoma cells.

dd><dt class="label">•dt><dd>

d="p0030">We suggest that PDEF is regarded as a tumor suppressor gene in human bladder cancer.

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