TRIM39 and RNF39 are associated with Behçet’s disease independently of HLA-B*51 and -A*26

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• 作者：Riho Kurata ; Hirofumi Nakaoka ; Atsushi Tajima ; Kazuyoshi Hosomichi ; Takashi Shiina ; Akira Meguro ; Nobuhisa Mizuki ; Shigeaki Ohono ; Ituro Inoue ; Hidetoshi Inoko
• 关键词：Behç ; et’ ; s disease ; HLA class I ; Logistic regression analysis ; TRIM39 ; RNF39
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2010
• 出版时间：29 October 2010
• 年：2010
• 卷：401
• 期：4
• 页码：533-537
• 全文大小：363 K

文摘

Behcet’s disease (BD) is a chronic inflammatory autoimmune disease and strongly associated with human leukocyte antigen (HLA)-B*51 and -A*26. We examined whether other genetic factors may exist in HLA region by 135 single nucleotide polymorphisms (SNPs) in 384 pairs of Japanese BD patients and controls. Multiple logistic regression analysis identified two novel susceptibility SNPs: rs9261365 near a ring finger protein (RNF) 39 and rs2074474 on exon 9 of tripartite motif-containing (TRIM) 39 independently of HLA-B*51 and -A*26 alleles. Our findings suggest that RNF39 and TRIM39 are involved in the etiology of BD.